Acute effects of alcohol on
regional cerebral blood flow.
Acute effects of alcohol in a low (0.7 g/kg) and a high dose (1.5
g/kg) on regional cerebral blood flow (rCBF) were measured with
133Xe inhalation technique at resting conditions in 13 normals. Mean
hemisphere CBF increased globally by 12% at the lower dose and 16%
at the higher dose. A normal hyperfrontal flow pattern was seen in
both alcohol conditions. There were, however, significant regional
differences in response to alcohol. The largest rCBF increase was
observed in prefrontal regions at the lower dose, and in temporal
regions at the higher. Expressed in relative values (% of the whole
brain CBF), the temporal rCBF increased linearly with increasing
alcohol dosage, while the prefrontal rCBF showed a increase at the
lower dose followed by a decrease at the higher dose. It is
concluded that alcohol has two types of acute effects on rCBF, a
global vasodilatory effect and some regional effects, most clearly
seen in prefrontal and temporal regions. The prefrontal flow
augmentation following acute alcohol intake may be related to a
transient arousal reaction, which has been reported by others. The
temporal flow increase may be related to effects of alcohol on
emotions and mood.
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