The pattern of
regional cerebral blood flow during
alcohol withdrawal
--a single photon emission
tomography study with 99mTc-HMPAO
Cerebral blood flow was investigated during
alcohol withdrawal in 15
male alcoholics by single photon emission computerized tomography
with 99mTc-HMPAO and compared with the results of a second study 3
weeks later when all symptoms of withdrawal had disappeared and when
the patients had been free of medication for at least 1 week. Slice
images were reconstructed parallel to the orbitomeatal plane, and
tracer activity was analyzed in 8 regions of interest per
hemisphere. During alcohol withdrawal a special pattern of cerebral
blood flow distribution could be observed. Relative perfusion was
elevated in both inferior temporal regions, whereas it was reduced
in the superior temporal region of both hemispheres. The changes of
cerebral blood flow distribution did not correlate with
neuropsychological findings nor with the severity of withdrawal
syndrome.
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