Abstinence improves cerebral
perfusion and brain volume in
alcoholic neurotoxicity
without
Wernicke-Korsakoff syndrome.
Twenty severe chronic alcoholic patients with signs of neurotoxicity
but without Wernicke-Korsakoff syndrome were treated by abstinence
from alcohol and examined prospectively at intervals thereafter.
Serial examinations included detailed medical histories,
neurological examinations, cognitive capacity screening
examinations, computed tomography scans with measurements of sulcal
and ventricular volume, and measurements of regional CBF. All
sedatives were withdrawn before CBF measurements were made. Before
treatment, gray matter blood flow values were significantly reduced
compared with those of age-matched normal volunteers, but white
matter blood flow values were normal and the ventricles were
enlarged. After abstinence from alcohol, mean gray matter blood flow
values and brain volume both increased significantly.
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