Regional cerebral
blood flow in chronic
alcoholics measured by single photon
emission computerized tomography.
Regional cerebral blood flow (CBF) was measured by single photon
emission computerized tomography of inhaled 133-Xe in 20 chronic
alcoholic men. Mean CBF was 51 ml/(100 g x min) compared with 53
ml/(100 g x min) in 20 normals. Reduced cerebellar blood flow
correlated both to structural abnormalities seen on CT scan and to
cognitive dysfunction. Slight abnormalities of the regional CBF was
observed in the alcoholics. They had a higher incidence of regional
low flow areas than a control group. Low flow areas were found in
frontal and posterior parts of the brain not only in patients with
atrophia, but also in patients without CT abnormalities, suggesting
neuronal dysfunction. The occurrence of regional low flow areas was
associated with the severity of alcoholism, cerebral atrophy and
intellectual impairment.
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