Twenty-two institutionalized alcoholics were studied after 1, 3, 5
and 7 weeks of abstinence with measurements of the regional cerebral
blood flow (rCBF), psychometric testing and clinical ratings.
Twenty-two healthy volunteers served as age-matched controls. Mean
rCBF was significantly reduced in the alcoholics at all measurements
compared to the controls. The older alcoholics (median cut) showed a
9% increase of rCBF from the 1st to the 7th week (P less than 0.01).
The mean rCBF in these alcoholics also increased more in the right
than in the left hemisphere (P less than 0.05) during the
investigation. The differences between the alcoholics and the
controls were most pronounced in the right frontal lobe. The mean
flow changes were correlated to improvement in clinical state. Right
hemisphere and frontal lobe flow decreases were more accentuated in
older alcoholics.
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