Cannabis induced dopamine release: an in-vivo SPECT study.
Voruganti LN, Slomka P, Zabel P, Mattar A, Awad AG.
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Psychiatry Res 2001 Oct 1;107(3):173-7
In a research study aimed at examining the alterations in dopaminergic function in schizophrenia, the authors identified a surreptitious case scenario which provided new insights into the subjective and neurochemical effects of cannabis. A 38-year-old drug-free schizophrenic patient took part in a single photon emission computerized tomographic (SPECT) study of the brain, and smoked cannabis secretively during a pause in the course of an imaging session. Cannabis had an immediate calming effect, followed by a worsening of psychotic symptoms a few hours later. A comparison of the two sets of images, obtained before and immediately after smoking cannabis, indicated a 20% decrease in the striatal dopamine D2 receptor binding ratio, suggestive of increased synaptic dopaminergic activity. This observation offers a plausible biological explanation for the psychotogenic effects of cannabis in vulnerable individuals, and also raises speculations about an interaction between cannabinoid and dopaminergic systems in the brain reward pathways.
It starts with a phone call. Why not call now??
Our call center is ready to help you navigate through the maze of decisions that leads to proper treatment, recovery and sanity.