assessed by single photon emission computed
tomography.
Bhatara VS; Lovrein F; Kirkeby J;
Swayze V; Unruh E; Johnson V.
S D J Med 2002 Feb;55(2):59-62
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This case series reports results of
single photon emission computed tomography (SPECT) studies in three
patients with fetal alcohol syndrome (FAS), who had previously
undergone structural magnetic resonance imaging (MR). The MR studies
revealed several brain anomalies, including microcephaly, agenesis
or hypoplasia of corpus callosum and agenesis of hippocampal
commissure. The SPECT data revealed that the CBF was reduced by at
least 25% in the temporal region relative to the cerebellum in all
three patients. By contrast, the temporal-cerebellar differences
were between 4% and 7% in two controls. The functional abnormalities
in FAS, like neuroanatomical abnormalities, are likely to be
multiple and varied because of heterogeneity of this syndrome. Our
findings suggest the need for a larger study to test the hypothesis
that temporal lobe abnormalities are a notable occurrence in FAS.
Discovery of specific regional brain dysfunctions (such as temporal
lobe dysfunction) that are particularly vulnerable to alcohol's
teratogenic effect may allow clinicians and researchers to look for
markers useful in FAS screening and may have implications for
prevention and treatment of FAS.
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