Abnormal structure of human
striatal dopamine re-uptake sites in habitually
violent alcoholic
offenders:
a fractal analysis.
Kuikka JT, Tiihonen J, Bergstrom KA,
Karhu J, Rasanen P, Eronen M.
Department of Clinical Physiology, Kuopio University Hospital,
Finland
Neurosci Lett 1998 Sep 11;253(3):195-7
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Both animal and human studies imply that aggressive behaviour is
associated with increased dopaminergic transmission. Our hypothesis
was that impulsive violent offenders have also higher heterogeneity
of the striatal dopamine transporter (DAT) density than controls. We
performed a fractal analysis in 21 impulsive violent offenders, 10
non-violent alcoholics and 21 controls to measure the heterogeneity
and laterality of the striatal DAT density characterised by
[123I]beta-CIT single-photon emission tomography (SPET). The
[123I]beta-CIT distribution was significantly more heterogeneous in
the right striatum of violent offenders than in healthy controls. In
addition, in young violent offenders there was no normal
left-to-right asymmetry observed in control subjects of the same
age. The normalisation of the left-to-right asymmetry may reflect
late neurobiological maturation.
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